Crohn's Disease
Conditions
Interventions
Gold Standard:Histology pathological examination
SES-CD endoscopy score
test 
for 
serum 
cytokines
Sponsors
The First Hospital Affiliated to Sun Yat sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Crohn's Disease in endoscopy, histology and imageology; 2. Moderate or severe CD patients: in active stage of disease (CDAI>150); in active stage of endoscopy (ses-CD>2 or rutgeerts score>1); 3. Injection times of inflixmab >= 4.
Exclusion criteria
Exclusion criteria: 1. Received anti TNF treatment in the past year; 2. Participate in other clinical experiments; 3. There are other contraindications, including heart failure, active tuberculosis, acute infection, active infection: hepatitis B, hepatitis C, HIV, CMV, Clostridium difficile infection; 4. Stop IFX treatment due to allergy, infusion reaction, combined infection and other factors; delay injection; no serum; loss of follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SERUM CRP;serum ESR;serum IL1;serum IL13;other serum inflammatory factors;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactZhang Shenghong
The First Hospital Affiliated to Sun Yat sen University
Outcome results
None listed