delirium
Conditions
Interventions
Experimental group:Dexmedetomidine
Control group:none
Sponsors
Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients aged 18-60 years who had no serious disease history and signed informed consent were included in the study. The control group was healthy volunteers of the same age group who were used to control the data of fMRI resting state.
Exclusion criteria
Exclusion criteria: (1) patients who could not cooperate with preoperative neurocognitive assessment and preoperative functional MRI; (2) patients with mental disease; (3) patients with history of hydrocephalus, cerebral infarction and cerebral hemorrhage; (4) patients with history of epilepsy and taking antiepileptic drugs; (5) patients who had taken sedative or analgesic drugs within 24 hours after the start of the study; (6) Patients with drug and alcohol abuse; (7) perinatal and lactation patients; (8) patients with recurrent intracranial tumors; (9) patients with multiple intracranial tumors; (10) patients with surgery who have received radiotherapy or chemotherapy; (11) patients with claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of neural compensation network in fMRI; | — |
Countries
China
Contacts
Public ContactGuobin Zhang
Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed