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Dexmedetomidine attenuates perioperative inflammatory responses in patients with traumatic brain injury

Dexmedetomidine attenuates perioperative inflammatory responses in patients with traumatic brain injury

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000029501
Enrollment
Unknown
Registered
2020-02-03
Start date
2010-02-10
Completion date
Unknown
Last updated
2020-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anesthesia for craniocerebral trauma

Interventions

control group:normal general anesthesia
Experimental group:added dexmedetomidine as adjuvent for general anesthesia

Sponsors

Handan Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 68 Years

Inclusion criteria

Inclusion criteria: ASA status I-IV adult patients (20-68 years old) with craniocerebral trauma who required a decompressive craniectomy within the next 24 hours.

Exclusion criteria

Exclusion criteria: Patients with spinal cord injury, heart disease, hepatic disease, kidney disease, dysrhythmia, mean arterial blood pressure (MAP) lower than 60 mmHg, or an allergy to study drugs; pregnant or lactating women

Design outcomes

Primary

MeasureTime frame
blood pressure;heart rate;The Glasgow Coma Scale;IL6;TNFalpha;Neuron Specific Enolase (NSE);—

Countries

China

Contacts

Public ContactYongxue Chen

Handan Central Hospital

yongxuechen2019@163.com+86 15533095559

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026