Correlation analysis of genetics and corneal topography and biomechanics of parent and offspring keratoconus

Correlation analysis between keratoconus genetic genes and corneal topography and biomechanics

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000029484

Enrollment

Unknown

Registered

2020-02-02

Start date

2020-02-06

Completion date

Unknown

Last updated

2020-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

genetic of keratoconus

Interventions

keratoconus group:N/A

parents of patients with keratoconus:N/A

control group:N/A

Eligibility

Sex/Gender

All

Age

10 Years to 60 Years

Inclusion criteria

Inclusion criteria: With a history of myopia myopic astigmatism; central corneal thinning conical protrusion, and Munsons sign, vogts striae or Fleischers ring on slit-lamp examination, along with signs of KC topographic characteristics (displacement of the corneal apex, decrease in thinnest-point pachymetry, asymmetric topographic pattern).

Exclusion criteria

Exclusion criteria: Eyes with stromal scarring or corneal inflammation, history of glaucoma, corneal or ocular surgery, trauma or systemic diseases known to affect the eyes, or poor cooperation for reliable examination. In addition, the soft contact lens wear was discontinued at least 2 weeks and rigid contact lenses were discontinued at least 4 weeks before the examination.

Design outcomes

Primary

Measure	Time frame
corneal topograpy;biomechanical indexes;	—

Countries

China

Contacts

Public ContactDu Xianli

Shandong Eye Instiute, Qingdao Eye Hospital

lilibestever@126.com+86 15192552255

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026