disorder of sexual development
Conditions
Interventions
Case series:Nil
Sponsors
The Children's Hospital, Zhejiang University School Of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: The following conditions in the neonatal physical examination suggest the possibility of DSD: (1) Obvious genital obscuration (such as cloaca eversion); (2) The female genitalia are obvious characteristics, but the clitoris is enlarged and the posterior labia is fused (such as CAH); (3) Male genitalia are obvious, but there are bilateral cryptorchidism, hypospadias, or small penis; (4) The appearance of the genitals is not consistent with the prenatal karyotype diagnosis. Infants, children, adolescents, and adolescents undergo physical examination to find the following abnormalities, suggesting that DSD may be: (1) Unclear gender characteristics of genitals; (2) Inguinal hernia (such as CAIS) in girls; (3) Delayed pubertal development or incompatible genital phenotype and rearing gender (such as abnormal increase in clitoris in adolescence); (4) Primary amenorrhea or virilization of women; (5) Feminization of male breasts; (6) Periodic severe hematuria in men.
Exclusion criteria
Exclusion criteria: (1) Clear diagnosis of disorder of sexual development; (2) Other chromosomal abnormalities with disorder of sexual development; (3) Abnormal sexual differentiation affected by drugs and environment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gene test; | — |
Secondary
| Measure | Time frame |
|---|---|
| height;weight;Sexual development;sexual hormone;Electrolyte determination; | — |
Countries
China
Contacts
Public ContactFu Junfen
The Children's Hospital, Zhejiang University School Of Medicine
Outcome results
None listed