Childhood acute lymphocytic leukemia
Conditions
Interventions
mediate risk:Target drug plus chemotherapy
high risk:Target drug plus chemotherapy plus transplantation
Sponsors
Beijing Children's Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged 0-18 years; 2. From 2020 to 2025, children with PH positive and PH like all in our hospital; 3. No treatments were carried out in the previous 1 month or only received less than 3 days of glucocorticoids, one dose of vinblastine, one intrathecal injection or urgent diagnosis and radiotherapy due to mediastinal compression in the week before enrollment; 4. Were diagnosed as acute lymphoblastic leukemia by MICM classification, confirmed as PH positive ALL and PH like ALL by PCR, second-generation sequencing technology and fish technology; 5. Have signed the informed consent. The expression levels of BCR-ABL1 fusion gene, pH like all gene and crlf2 gene were detected by multiple fluorescence qualitative PCR and next generation sequencing. In this project, 59 partners of abl1, abl2, csf1r, PDGFRA, Lyn, crfl2, JAK, EPOR and TSLP 10 fusion points can be identified to form the fusion gene (see Table 2). The break point or high expression of crfl2 was detected by FISH method or flow cytomet
Exclusion criteria
Exclusion criteria: Relapsed ALL, pH positive and pH like mixed leukemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| minimal residual disease; | — |
Countries
China
Contacts
Public ContactZhang Ruidong
Beijing Children's Hospital
Outcome results
None listed