pediatric hematopoietic stem cell transplantation
Conditions
Interventions
Sponsors
Children's Hospital of Shanghai
Eligibility
Sex/Gender
All
Age
0.8 Years to 16 Years
Inclusion criteria
Inclusion criteria: 1. Aged 1-18 years old; 2. Met the transplantation indications and had the intention of transplantation; 3. Before transplantation, the blood routine, liver and kidney function, complete virus set, HLA antibody screening, ECG, cardiac ultrasound, lung function, lung CT and other examinations were completed, excluding the contraindications for transplantation; 4. Before transplantation, allo-HSCT was not accepted; Criteria for cord blood screening: 8 cord blood banks across China inquired for the right cord blood, expanded the scope of screening in order to find more satisfactory cord blood; according to the HLA antibody screening results, DSA positive cord blood was eliminated; HLA matching was the priority factor, and HLA >=4 / 6 loci (HLA-A, B, drbl site serological matching) were matched between donors; the next was the number of cord blood CD34 +, which should be at least > 1x10^5/kg; Our center initially determined the order of cord blood selection: HLA matching > CD34 + number > blood type > gender source.
Exclusion criteria
Exclusion criteria: 1. organ dysfunction or dysfunction can not tolerate pretreatment; 2. previous allo-HSCT; 3. acquired immunodeficiency disease; 4. any significant abnormal coexisting disease or mental illness, affecting the patient's life safety and compliance, affecting informed consent, research participation, follow-up or result interpretation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hematopoietic reconstitution;Immune reconstruction;Stem cell implantation;Graft versus host disease;infection;Hemorrhagic cystitis; | — |
Countries
China
Contacts
Public ContactKai Chen
Children's Hospital of Shanghai
Outcome results
None listed