Including but not limited to liver occupying, pancreaticoduodenal diseases, gastrointestinal diseases
Conditions
Interventions
Case series in stage I (not randomized):During the operation, the blood pressure should be controlled within the range of cerebral autoregulation
Control group:Conventional anesthesia and monitoring
Experimental group:During the operation, the blood pressure should be controlled within the range of cerebral autoregulation
Sponsors
Department of Anaesthesiology, The First Affiliated Hospital, Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Stage 1 inclusion criteria: (1) aged from 18 to 85 years; (2) patients undergoing non-emergency third-grade to fourth-grade surgery under general anesthesia; (3) ASA(American Society of Anesthesiologists) class I ~ III; (4) the operation is expected to last from 3 to 8 hours; (5) participate in the study voluntarily and sign the informed consent; Stage 2 inclusion criteria: (1) aged from 18 to 85 years; (2) patients undergoing non-emergency third-grade to fourth-grade surgery under general anesthesia; (3) ASA(American Society of Anesthesiologists) class I ~ III; (4) the operation is expected to last from 3 to 8 hours; (5) participate in the study voluntarily and sign the informed consent.
Exclusion criteria
Exclusion criteria: Stage 1 exclusion criteria: (1) arrhythmia (frequent atrial fibrillation and ventricular premature beats), history of myocardial infarction,history of cardiac surgery,congestive heart failure (the ejection fraction is less than 50%,or clinical manifestations such as decreased exercise tolerance and fluid retention), valve diease; (2) the placement of the brain oxygen probes affect the operation; (3) history of central nervous system disease or surgery; (4) patients who are unable to cooperate with mental stress, or who suffer from mental illness and have no self-control to express clearly; (5) participating in other clinical trials; (6) for other reasons, the researchers concluded that the study was inappropriate for the patient; Stage 2 exclusion criteria: (1) arrhythmia (frequent atrial fibrillation and ventricular premature beats), history of myocardial infarction,history of cardiac surgery,congestive heart failure (the ejection fraction is less than 50%,or clinical manifestations such as decreased exercise tolerance and fluid retention), valve diease; (2) the placement of the brain oxygen probes affect the operation; (3) history of central nervous system disease or surgery; (4) patients who are unable to cooperate with mental stress, or who suffer from mental illness and have no self-control to express clearly; (5) participating in other clinical trials; (6) for other reasons, the researchers concluded that the study was inappropriate for the patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral oximetry index, COx;Tissue Hemoglobin index, THx;Postoperative complications; | — |
Countries
China
Contacts
Public ContactKaizhi Lu
Department of Anaesthesiology, The First Affiliated Hospital, Army Medical University
Outcome results
None listed