Knee osteoarthritis
Conditions
Interventions
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. KOA chronic pain subjects inclusion criteria (1) Meet the diagnostic criteria of traditional Chinese and Western medicine for knee osteoarthritis; (2) Aged 18 to 65 years old male and female, right-handed; (3) Kellgren-Lawrence radiological score is I-II; (4) Knee joint pain lasts for more than 3 months; VAS score >=3 points; (5) Occupation: non-physical workers (such as teachers, employees of enterprises and institutions, etc.), no violent lower extremity activities; (6) Understand and agree to participate in this study and sign the informed consent. 2. Inclusion criteria for asymptomatic KOA subjects (1) Once met the diagnostic criteria of traditional Chinese and Western medicine for knee osteoarthritis; (2) Aged 18 to 65 years old male and female, right-handed; (3) Kellgren-Lawrence radiological score is I-II; (4) Knee joint has no pain in the last 3 months; VAS score = 0; (5) Occupation: Non-physical workers (such as teachers, employees of enterprises and institutions, etc.), no violent lower limb activities in daily life; (6) Understand and agree to participate in this study and sign the informed consent. 3. Healthy subjects: (1) Aged 18 to 65 years old male and female; (2) good health; (3) Right-handed.
Exclusion criteria
Exclusion criteria: KOA chronic pain subjects: 1. Take painkillers or anesthetics in the last 1 month; 2. who received any other treatment within the last 1 month; 3. pregnant or lactating women; 4. suffer from mental illness, neurological disease, infectious disease, gastrointestinal disease, cardiovascular and cerebrovascular disease, immunological disease, respiratory disease or kidney disease; 5. have tumors, tuberculosis, rheumatism or rheumatoid arthritis, gout, joint trauma, or any other chronic pain symptoms, or have a history of brain trauma with loss of consciousness; 6. Patients with MRI contraindications such as atresia, pacemaker, defibrillator, cardiac stent, and intrauterine device; 7. Defects or ulcers on the skin around the knee joint; Asymptomatic KOA subjects: 1. Patients with MRI contraindications such as atresia, pacemaker, defibrillator, cardiac stent, and intrauterine device; 2. Use of antipyretic, analgesic, sleeping or hormone drugs in the last week; 3. Pain occurred in the last 1 month; 4. History of cardiovascular, cerebrovascular, central nervous system disease, mental illness or head trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Based on VBM analysis indicators;Based on fMRI analysis indicators;Based on DTI analysis indicators;McGill Pain Questionnaire;WOMAC scale;VAS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain domain;Muscle tension;Chinese Emotional Quotient Questionnaire;Hamilton Depression Scale (HAMD);Hamilton Anxiety Scale (HAMA);Chinese pain sensitivity scale;Interpersonal Response Index Scale;Lysholm scale;SF-36 scale;HAD scale; | — |
Countries
China
Contacts
Public ContactFang Min
Institute of Tuina, Yueyang Hospital
Outcome results
None listed