Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
Group 1:Xuebijing Injiection
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. New coronavirus-infected pneumonia confirmed by pathogenic detection; 2. Meet the diagnostic criteria for community-acquired pneumonia (based on 2019 ATS/IDSA diagnostic criteria); 3. Pneumonia Severity Index (PSI) III-V or Oxygenation Index (P/F)<=300 mmHg; 4. Aged 18 to 75 years; 5. Obtain informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactating women; 2. People with allergies or allergies to Xuebijing injection and its components; 3. Severe basic diseases that affect survival, including: uncontrolled malignant tumors with multiple metastases that cannot be removed, hematological diseases, cachexia, active bleeding, severe malnutrition, HIV, etc.; 4. Obstructive pneumonia caused by lung tumors, severe pulmonary interstitial fibrosis, alveolar proteinosis, allergic reaction alveolitis; 5. Previous immunosuppressive agents within 6 months before study entry or recipients of a solid-organ or bone marrow transplant; 6. Extracorporeal life support (ECMO, ECCO2R, RRT); 7. Expected to die within 48 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pneumonia severity index (PSI); | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day prognosis;oxygenation index;SOFA;DIC;ABG;myocardial enzyme;CRP;PCT;HLA-DR;Immunoglobulin concentration;hepar and renal function;Length of stay in ICU and/or hospital;chest imaging;Mechanical ventilation time; | — |
Countries
China
Contacts
Public ContactZhong Nanshan / Song Yuanlin/Qiu Haibo/Li Yimin/Liu Xiaoqinqing
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed