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A prospective randomized controlled study on the effect of growth hormone (GH) combined with metformin (Met) in improving the reproductive outcome of assisted pregnancy in infertile patients with low ovarian reserve function

A prospective randomized controlled study on the effect of growth hormone (GH) combined with metformin (Met) in improving the reproductive outcome of assisted pregnancy in infertile patients with low ovarian reserve function

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000029341
Enrollment
Unknown
Registered
2020-01-25
Start date
2020-02-17
Completion date
Unknown
Last updated
2020-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility, DOR

Interventions

Group A:GH combined with Metformin, COS
Group B:COS

Sponsors

West China Second University Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Aged between 20-40 years old; infertility; regular menstruation; normal male semen; patients with IVF indications and DOR.

Exclusion criteria

Exclusion criteria: Contraindications to IVF (any party providing eggs or sperm has an unhealthy habit of drinking or taking drugs, or is exposed to teratogenic amount of rays, poisons or drugs that are in active effect. The woman suffers from serious genetic diseases, physical diseases, mental and psychological disorders, etc. that are not suitable for childbearing); the woman has a history of unilateral ovariectomy, abnormal uterine development,intrauterine adhesions, endometrial tuberculosis, or systematic diseases including but not limited to: hypertension, diabetes, hyperlipidemia, rheumatism or rheumatoid diseases and other immune system diseases; patients who are participating or plan to participate in other clinical studies.

Design outcomes

Primary

MeasureTime frame
pregnant rate;rate of good quality embryo;

Secondary

MeasureTime frame
numbers of retrieved oocytes;rate of MII oocytes;rate of good quality embryo;embryo implantation rat;

Countries

China

Contacts

Public ContactHuang Wei

West China Second University Hospital, Sichuan University

weihuang64@163.com+86 13881858999

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026