Anesthesia for tonsillectomy in children
Conditions
Interventions
group nalbuphine:nalbuphine iv 0.2 ml/kg
group control:saline iv
Sponsors
The First People's Hospital of Foshan
Eligibility
Sex/Gender
All
Age
3 Years to 9 Years
Inclusion criteria
Inclusion criteria: (1) Adenoidectomy under general anesthesia in children aged 3-9 years; (2) ASA I-II; (3) Body mass index 18-23; (4) Children's families voluntarily participate in and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Known or suspected to be allergic or contraindicated to various components of the study drug or other opioid drugs; (2) Analgesic, sedative, antiemetic and anti pruritus drugs were used 24 hours before operation; (3) patient in shock or coma; (4) Patients with asthma or respiratory depression; (5) Brain injury, intracranial injury or existing intracranial hypertension; (6) Long term use of analgesics, psychoactive drugs (including opioids, NSAIDs, sedatives, antidepressants, etc.); alcohol abuse, drug abuse and addiction in patients with chronic pain; (7) Liver and kidney function: when ALT and / or ast exceeds 1.5 times of the upper limit of the medical reference value, the serum creatinine or urea nitrogen exceeds the normal value; (8) Severe arrhythmia, cardiac insufficiency (NYHA grade >= III), unstable angina pectoris, acute myocardial infarction within the past 6 months, patients who did not receive regular antihypertensive treatment or poor blood pressure control (SBP >= 160 mmHg and / or DBP >= 100 mmHg), or patients who (SBP <= 90 mmHg and / or DBP <= 60 mmHg); (9) Those who are unable to give full informed consent due to mental disorders and cannot express their wishes correctly; (10) A patient with a known history of neurological abnormalities, such as seizures; (11) Those who have received any other investigational drug within 3 months before inclusion; (12) The researcher judged that the subjects' compliance was not good and could not strictly implement the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PAED scores;pain intensity; | — |
Secondary
| Measure | Time frame |
|---|---|
| the time to eye opening;the time to extubation;Time for the body to return to conscious movement;time to recovery;incidence of nausea and vomiting;incidence of respiratory inhibition;satisfaction of medical staff,;satisfaction of guardians;time duration stay in PACU; | — |
Countries
China
Contacts
Public ContactWang Hanbin
Department of Anesthesiology, the First People's Hospital of foshan
Outcome results
None listed