low-grade gliomas
Conditions
Interventions
High dose group:54Gy radiation
Low dose group:45Gy radiation
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Karnofsky performance score >=60; 3. Patients with low-grade gliomas must also be considered "high risk" by exhibiting one of the following characteristics: Age >= 40 and any surgical therapy; Age =100 x10^9/L, Hemoglobin >=100g/L; 7. TBIL<=1.5 times the lab's upper normal limit, AST or ALT < 1.5 times the lab's upper normal limit; 8. Serum creatinine < 1.5 times the lab's upper normal limit; 9. Adequate medical health to participate in this study; 10. No previous systemic chemotherapy and radiotherapy to the brain; 11. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. No pathological confirmation; 2. Second cancer requiring radiotherapy or chemotherapy; 3. Serious medical or neurological condition with a poor prognosis; 4. Contraindications to radiotherapy or temozolomide chemotherapy; 5. Patient unable to follow procedures, visits, examinations described in the study; 6. Inability to undergo gadolinium-contrasted MRIs; 7. Pregnant women or nursing mothers can not participate in the study; 8. Not suitable for this study who to be confirmed by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival;Health-related quality of life; | — |
Secondary
| Measure | Time frame |
|---|---|
| Free Progression Survival;Hematologic Toxicity; | — |
Countries
China
Contacts
Public ContactXiaoguang Qiu
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed