Cough caused by sufentanil during general anesthesia induction
Conditions
Interventions
R1 group:Given Remifentanil 0.1 ug/kg intravenously before induction
R2 group:Given Remifentanil 0.2 ug/kg intravenously before induction
R3 group:Given Remifentanil 0.3 ug/kg intravenously before induction
R4 group:Given Remifentanil 0.4 ug/kg intravenously before induction
R5 group:Given Remifentanil 0.5 ug/kg intravenously before induction
C group :Given equal volume of normal saline intravenously before induction
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~70 years old; 2. BMI: 18~30kg/m2; 3. ASA I~II grade; 4. Patients undergoing elective general anesthesia surgery.
Exclusion criteria
Exclusion criteria: 1. Obese patients (BMI>30 kg/m2); 2. Pregnant and childbirth patients; 3. Smoking; 4. Combined respiratory diseases: such as asthma, COPD, pulmonary bullae, upper respiratory tract infection within two weeks; 5. With elevated intracranial pressure, intraocular pressure or abdominal pressure; 6. History of hypertension; 7. Preoperative bradycardia; 8. Patients with severe cardiovascular and cerebrovascular, liver and kidney and hematopoietic diseases; 9. Patients with cognitive or mental illness; 10. Opioid dependent or long-term users; 11. Long-term use of drugs that cause cough such as angiotensin converting enzyme inhibitor (ACEI); 12. Long-term use of bronchodilators and cough suppressants; 13. History of allergic reactions to related drugs; 14. Those who participated in other clinical trials or researchers considered it inappropriate to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coughing times; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate; | — |
Countries
China
Contacts
Public ContactJiehao Sun
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed