Crohn's disease
Conditions
Interventions
Experimental group:Laparoscopic bowel resection combined with postoperative Infliximab treatment
Control group:Infliximab
Sponsors
Renji Hospital, School of Medicine, Shanghai Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age in between 18 and 80 years; 2. ASA I~II level; 3. Localized intestinal Crohn's disease (Intestinal CD affecting 220 points); 5. CD patients with high risk factors, including combined perianal lesions, small age of onset, corticosteriods therapy for the first treatment; 6. Patients have sufficient organ function; 7. Patients or family members are able to understand the study and sign an informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous use of IFX treatment; 2. Concomitant IFX contraindications, including: various types of heart disease (viral myocarditis, etc.), acute infection period, demyelinating diseases of the nervous system, and various infectious diseases such as tuberculosis, hepatitis B, and cytomegalovirus infection; 3. Abdominal abscess, cellulitis or ascites; 4. Insufficient surgery such as severe emphysema, pulmonary bullae, interstitial pneumonia or ischemic heart disease; 5. Pregnant or lactating women; 6. Severe mental illness; 7. Continuous systemic steroid treatment within 1 month; 8. There are contraindications for laparoscopic surgery; 9. Combining malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endoscopic remission; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical remission;Surgery rate;Life quality;Crohn's disease related consumption;Crohn‘s disease related morbidity; | — |
Countries
China
Contacts
Public ContactYu Minhao
enji Hospital, School of Medicine, Shanghai Jiaotong University
Outcome results
None listed