Spastic limb paralysis after central nervous system injury
Conditions
Interventions
Group 1:improved contralateral seventh cervical nerve transfer with conventional rehibilitation
Group 2:conventional contralateral seventh cervical nerve transfer with conventional rehibilitation
Sponsors
Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Spastic hemiplegia following different causes of central neurologic injury, such as stroke, traumatic brain injury, and cerebral palsy,majorly presenting but not limited to difficulty in hand-open; 2. Aged 45-65 years old; 3. At least one year and no more than 5 years, after sick . The patients have received regular rehabilitation therapy for at least 6 months, and ceased improving in the paralyzed hand; 4. Central neurologic injury only involving the hemisphere contralateral to the paralyzed hand, as indicated by brain MRI scans; 5. The paralyzed hand is controlled by the ipsilesional hemisphere exclusively, as indicated by transcranial magnetic stimulation (TMS); 6. Willing (or their parents were willing if the patients were underage) to receive surgeries to achieve further functional improvement; 7. The patients can fully understand and agree to the doctor's treatment plan and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Central nervous system damage involving both hemispheres of the brain; 2. Presence of severe, deformity or joint contracture; 3. Main presentation is ankylosis of joints; 4. Presence of severe systemic diseases such as diabetes mellitus or cardiopulmonary diseases,contraindicating surgery; 5. Personal or relatives decision to refuse surgery; 6. Psychological or mental abnormalities; 7. Developmental delay or low cognitive ability.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total score change of upper limb Fugl-Meyer scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| total score change of upper limb improved Ashworth scale;Functional Use;Neurological electrophysiology;functional MRI;Muscle strength;Tactile sensation;two-point discrimination; | — |
Countries
China
Contacts
Public ContactZairong Wei
Affiliated Hospital of Zunyi Medical University
Outcome results
None listed