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Calcium Autonomic Denervation Prevents Postoperative Atrial Fibrillation in Patients Undergoing isolated Aortic Valve Surgery

Calcium Autonomic Denervation Prevents Postoperative Atrial Fibrillation in Patients Undergoing isolated Aortic Valve Surgery

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000029313
Enrollment
Unknown
Registered
2020-01-24
Start date
2020-11-01
Completion date
Unknown
Last updated
2023-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Interventions

Sponsors

Department of Cardiovascular Surgery, General Hospital of Northern Theater Command
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Adults 40%; 6.Patients undergoing heart surgery for the first time; 7.Good compliance and ability to complete follow-up.

Exclusion criteria

Exclusion criteria: 1.History of AF; 2.Urgent or emergent cardiac surgery; 3.History of congenital heart diseases; 4.With mitral valve surgery; 5.Valve surgery is accompanied by other heart surgery; 6.Heart surgery is accompanied by surgery of other organ system; 7.Liver and kidney function abnormality (results exceed the upper limit of normal value by 3 times); 8.With valve surgery contraindications; 9.Patients suffer from other diseases who require radiotherapy, chemotherapy, and long-term hormone treatment; 10.Participated in other clinical trials; 11.Patients decline to consent.

Design outcomes

Primary

MeasureTime frame
Incidence of POAF (lasting more than 30 seconds) in both groups;

Secondary

MeasureTime frame
Days of hospital stay following surgery and ICU stay;Ventricular rate during AF;Inflammatory makers;Actionable AF: antiarrhythmic use (including rate-control meds), CDV, anticoagulation, use of inotropes for BP support during AF;Atrial fibrillation burden during the first week of operation;Number of episode > 24 hours, >48 hours;The incidence of Premature Atrial Contraction (PAC), Couplets and Nonsustained Atrial Tachyarrhythmia;

Countries

China

Contacts

Public ContactHui-Shan Wang

Department of Cardiovascular Surgery, General Hospital of Northern Theater Command

huishanwang@hotmail.com+86 13309885095

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026