Talaromyces marneffei
Conditions
Interventions
Sponsors
Guangzhou Institute of Respiratory Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria of T. marneffei patients: T. marneffei patients meeting any of the following criteria should be selected: (1) T. marneffei were observed in sputum, tracheal suction, BALF, lung biopsy, pleural effusion, bone marrow smear, skin exudate or lymph node smear after Wright's staining under microscope. The typical morphology of the T. marneffei was round or oval with obvious transverse septum (usually in macrophages); (2) T. marneffei was isolated from sputum, tracheal aspirate, BALF, lung biopsy, pleural effusion, bone marrow smear, skin exudate, lymph node smear or blood; (3) Histopathological examination of lung biopsy specimens, enlarged lymph node biopsy specimens or diseased skin specimens showed that there were T. marneffei, pyogenic granuloma, central necrosis and a large number of monocyte macrophages infiltration. 2. Inclusion criteria of healthy controls: (1) Not infected with T. marneffei. (2) No lung or systemic infection. (3) No definite hypoimmunity disease, tumor, chronic basic diseases such as diabetes, and other diseases which can affect local or systemic immunity. No long-term use of immunosuppressant, monoclonal antibody, hormone. (4) The age and sex of healthy controls were similar to T. marneffei patients. 3. Inclusion criteria of patients' relatives: (1) Immediate family of patients with positive genetic test, including parents, brothers, sisters, children.
Exclusion criteria
Exclusion criteria: HIV or AIDS patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| APACHE II ??;Infectious index;Routine blood test;Biochemical Indicators;TOI;Fungus; | — |
Countries
China
Contacts
Public ContactFeng Ye
Guangzhou Institute of Respiratory Health
Outcome results
None listed