A multicentre, randomized, controlled trial for thiamine and folate in the treatment of cognitive impairment in maintenance hemodialysis patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000029297

Enrollment

Unknown

Registered

2020-01-22

Start date

2020-02-01

Completion date

Unknown

Last updated

2020-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End stage renal disease and cognitive impairment

Interventions

Control group:nonintervention

Experimental group:thiamine and folic acid

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Maintenance dialysis hemodialysis (>=3 months); 2. Accompanied by cognitive impairment, definition: Montreal Cognitive Assessment (MoCA) score less than 26; If the length of schooling is less than or equal to 12 years, less than 25 points; 3. Aged 18-75, male or female; 4. Sign Inform Consent Form.

Exclusion criteria

Exclusion criteria: 1. Patients' medical records are missing or incomplete; 2. Unable to cooperate with the completion researcher; 3. The life expectancy is less than 1 year; 4. Participants in other clinical trials within three months; 5. Has the severe anemia infection tumor activity bleeding or the heart liver lung disease; 6. Thiamine and folic acid allergies; 7. Diseases that can cause cognitive impairment, such as some cerebrovascular diseases.

Design outcomes

Primary

Measure	Time frame
cognitive function;patient outcome;	—

Secondary

Measure	Time frame
Thiamine and folate levels;Homocysteine level;	—

Countries

China

Contacts

Public ContactRenhua Lu

Renji Hospital School of Medicine Shanghai Jiao Tong University

lurenhua1977@hotmail.com+86 13361958582

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 13, 2026