Diminished ovarian reserve
Conditions
Interventions
Experimental group:take letrozole 5mg orally for 5 consecutive days on the 2nd day of the menstrual cycle, subcutaneous gonadotropin 300U injection for 2 consecutive days on the 5th day of the menstru
Control group:subcutaneous gonadotropin 300U injection for 5 consecutive days on the 2nd day of the menstrual cycle
Sponsors
Sun Yat-Sen University
Eligibility
Sex/Gender
Female
Age
No minimum to 45 Years
Inclusion criteria
Inclusion criteria: 1. People with advanced age or diminished ovarian reserve: (1) aged from 40 to 45 years; (2) patients with ovarian reserve dysfunction: aged <40 years, combined with AFC <5 or AMH <1.2 ng/mL. 2. Proposed 1-3 cycle IVF or ICSI; 3. The patient agrees to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) AMH < 0.1 ng/mL; (2) unilateral or bilateral hydrosalpinx; (3) combined uterine diseases, such as uterine malformation (uterus unicornis, uterus bicornis, uterus duplex, uterus septus), adenomyosis, intrauterine adhesions, untreated endometrial polyps and/or submucosal fibroids; (4) Both spouses or one spouse have chromosomal abnormalities; (5) Male dysfunction, non-obstructive azoospermia or AZF gene microdeletion; (6) allergic to letrozole or Gn; (7) Patients with contraindications to assisted reproductive technology or pregnancy,such as uncontrolled diabetes, undiagnosed liver and kidney dysfunction, history of deep vein thrombosis, history of pulmonary embolism, history of cerebrovascular accident, uncontrolled hypertension , heart disease, suspected cervical cancer, endometrial cancer, breast cancer or previous medical history, undiagnosed vaginal bleeding; (8) Unable to follow up or poor compliance, or the investigator believes that there exist factors affecting the subject's participation in the trial or outcome evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative clinical pregnancy rate of one ovulation induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| number of retrieved oocytes;rate of pregnancy loss;live birth rate; | — |
Countries
China
Contacts
Public ContactXiaomiao Zhao
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Outcome results
None listed