periodontitis and type 2 diabetes
Conditions
Interventions
experimental group:immediate treatment
control group:delayed treatment
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Male or female, aged 35-70 years old; 2) According to the 1999 WHO diabetes diagnostic criteria, who has been diagnosed with type 2 diabetes for more than 6 months. 3) No change in diabetes medication in the past 3 months; 4) Patients with clinical diagnosis of "chronic periodontitis" with reference to the 1999 International Classification of Periodontal Diseases, and meet the individual-level severe periodontitis criteria proposed by the 2017 Chinese expert consensus: two or more teeth have: a. Probing depth (PD)> 6mm; b. Loss of attachment (AL) >= 5mm; c. Alveolar bone resorption exceeds 1/2 of root length. If there are only two affected teeth, the two affected teeth must be non-adjacent and at least in different quadrants. 5) There are >= 20 remaining teeth in the mouth. 6) Patients informed consent .
Exclusion criteria
Exclusion criteria: 1) Patients with extremely poor blood glucose control (fasting blood glucose > 11.4 mmol / L); 2) Rheumatism, rheumatoid, nephritis and other immune system diseases; 3) Those who have taken anticoagulants regularly in the past 3 months; 4) Those who used antibiotics in the past 3 months; 5) Treatment history of periodontal disease in the past 6 months; 6) Smoking more than 10 cigarettes / day in the past 6 months; 7) Pregnant women or women planning pregnancy during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of HbA1c from baseline to 6 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of PD from baseline to 3 and 6 months;Changes of CAL from baseline to 3 and 6 months;Changes of BOP from baseline to 3 and 6 months;Changes of PI from baseline to 3 and 6 months;Changes of HbA1c from baseline to 3 months;Changes of FPG from baseline to 3 and 6 months;Changes of CD4, CD8, CD4 / CD8 ratio from baseline to 3 months and 6 months; | — |
Countries
China
Contacts
Public ContactRong Shu
Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed