asthma
Conditions
Interventions
LAMA group:Phase I: ICS/LABA and LAMA
Phase II: ICS /LABA and Placebo
control group:Phase I: ICS /LABA and Placebo
Phase II: ICS/LABA and LAMA.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Adult patients ( >= 18 years of age) with stable asthma (no respiratory infection, asthma exacerbation, or change in maintenance therapy in the preceding 4 weeks) and confirmed by variable airflow obstruction were recruited. Variable airflow obstruction was defined as airway hyper-responsiveness in response to any standard challenge agent or positive bronchodilator reversibility test with more than 12% and 200 mL increase of forced expiratory volume in one second (FEV1) from the baseline. asthma were controlled or uncontrolled by step 4 or step 5 treatment of GINA.
Exclusion criteria
Exclusion criteria: The subjects were excluded if they were pregnant, had a cognitive impairment, current solid organ malignancy, or an inability to attend study visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung function;participants of non-neuronal cholinergic system;corticosteroid resistance;airway and systomatic inflammation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| ACQ;ACT;AQLQ; | — |
Countries
China
Contacts
Public ContactGang Wang
Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University
Outcome results
None listed