Prostate sarcoma
Conditions
Interventions
Drug-eluting microspheres:HepaSphere was loaded with doxorubicin to embolize tumor blood vessels with a drug-loaded embolization microsphere
PVA granules:Doxorubicin was slowly perfused through the prostatic artery and then embolized with PVA granules (pva-100)
Sponsors
Department of Interventional Radiology, the First Medical Center, Chinese PLA General Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Male aged >= 18; 2. Histopathologically diagnosed as prostate sarcoma with clinical stage T3-4N0M0; 3. Not suitable for local treatment such as radical surgery and/or radiotherapy, or disease progression after local treatment such as surgery and/or radiotherapy; 4. The patient can receive drug treatment in the past, but the disease progresses after drug treatment; 5. According to the efficacy evaluation criteria for solid tumors 1.1 (RECIST V1.1), there was at least one measurable lesion; 6. ECOG physical condition score: 0 or 1; 7. Expected survival time >= 12 weeks.
Exclusion criteria
Exclusion criteria: 1. Severe urinary tract infection (active phase); 2. Allergic to iodine contrast agent; 3. Refractory massive ascites; 4. ECOG physical condition score of 2 or above; 5. Those who cannot cooperate with mental disorders; 6. It is not expected to complete the postoperative follow-up; 7. Have uncontrolled clinically significant disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;1 year, 2 year survival rate;Improvement in living conditions;Success rate of surgical transformation; | — |
Countries
China
Contacts
Public ContactWang Maoqiang
The First Medical Center, Chinese PLA General Hospital
Outcome results
None listed