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Goal-directed perfusion to reduce acute kidney injury after pediatric cardiac surgery: a randomized trial

Goal-directed perfusion to reduce acute kidney injury after pediatric cardiac surgery: a randomized trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000029232
Enrollment
Unknown
Registered
2020-01-19
Start date
2020-04-01
Completion date
Unknown
Last updated
2020-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pediatric cardiac surgery

Interventions

Control group:The children in control group achieved 2.8 ~ 3.2L/ (min·m2) perfusion flow rate according to their weight, body surface area and CPB temperature.
Experimental group:In experimental group, DO2i, calculated by blood gas test results, was maintained over the minimum safety threshold which was obtained from the second part of the experiment during

Sponsors

Departement of Anesthesiology, West China Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Pediatric patients undergoing cardiopulmonary bypass in our hospital were eligible for participation if they met the following criteria: 1) aged ? 3 year; 2) undergoing elective cardiac surgery under CPB; 3) ASA I - III level; 4) there is written informed consent.

Exclusion criteria

Exclusion criteria: 1) redo cardiac surgery; 2) severe renal disease (receipt of dialysis or a serum creatinine level >3.0 mg/dL); 3) current infections (e.g. sepsis); 4) preoperative treatment with gentamicin and vancomycin in the last seven days; 5) preoperative treatment with radiotherapy; 6) preoperative treatment with extracorporeal life support; 7) incomplete clinical data that statistical analysis could not be completed; 8) deep hypothermic CPB.

Design outcomes

Primary

MeasureTime frame
The incidence of AKI after cardiac surgery, pRIFLE as the diagnostic criteria for AKI;

Secondary

MeasureTime frame
Regional cerebral or renal oxygen saturation;awake time;extubation time;length of stay in hospital;length of stay in intensive care unit;mortality rate;severe complications;Total fluid intake and output (including the incidence of postoperative RBC infusion and transfusion volume);VIS score;

Countries

China

Contacts

Public ContactRonghua Zhou

Departement of Anesthesiology, West China Hospital

wr.zhou@hotmail.com+86 18980601935

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 17, 2026