Allergic rhinitis
Conditions
Interventions
Group A (hydrogen-rich brine group):nasal irrigation
Group B (saline group):nasal irrigation
Sponsors
Department of Otolaryngology, Tongji University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) the subject shall be a Chinese citizen aged 18 to 65, regardless of gender. 2) subjects must be diagnosed with AR (allergic rhinitis) during screening and baseline follow-up Treatment guide, Chinese journal of otolaryngology, head and neck surgery, 2016,51 (01) : 6-24). Criteria for AR inclusion: at least 3 of the 4 symptoms of nasal itching, sneezing, runny nose and nasal congestion. And a score of 2 or more for at least two symptoms. 3) the subject is in good health and has no disturbance to the test schedule or operation or to the subject the safety of the resulting effects of clinically significant disease. 4) subject shall provide written informed consent, and subject shall be able to follow medication and follow-up schedule. 5) for fertile female subjects, urine HCG must be negative during screening.
Exclusion criteria
Exclusion criteria: 1) subjects with acute sinusitis and acute nasal infection. 2) any clinical abnormalities in vital signs or clinical ekg results at screening or baseline follow-up subjects with significant abnormalities. 3) cardiovascular, lung, kidney, liver, metabolic diseases, hematology or neuropathy of clinical significance Subjects with disease, or with compromised immune systems. 4) subjects with upper respiratory tract infection. 5) subjects with nasal septum deviation requiring corrective surgery. 6) subjects are members of the research team directly involved in this study. 7) complicated with nasal vestibular inflammation, nasal tumor and other nasal diseases. 8) family planning within three months. 9) have participated in a clinical drug trial within three months. 10) use drugs that may affect the test results and stop taking the drugs for less than the prescribed time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal and eye symptom scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood immune index;Nasal resistance;Nasal nitric oxide;Number of eosinophil cells in nasal secretions;Eosinophilic cationic protein of Nasal discharge; | — |
Countries
China
Contacts
Public ContactYu Shaoqing
Department of Otolaryngology, Tongji University Affiliated Hospital
Outcome results
None listed