First-episode Schizophrenia
Conditions
Interventions
Gold Standard:the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
emotion 
model 
based 
on 
the 
circuit
Sponsors
Tongji Hospital of Tongji University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: First-episode schizophrenia with high social cognition group: 1. Meet the diagnostic criteria for schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); 2. MSCEIT scale score> 59.2 points (consensus points); 3. Aged 18 to 45 years, able to cooperate with task-state functional magnetic resonance testing; 4. First onset, not receiving systemic antipsychotic therapy (not receiving sufficient medication for more than 3 months or never receiving medication); 5. Wechsler Intelligence Scale assesses IQ> 70. First-episode schizophrenia with low social cognitive group: 1. Meet the diagnostic criteria for schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); 2. MSCEIT scale score 70. Healthy control group: 1. Aged 18 to 45 years; 2. Wechsler Intelligence Scale assesses IQ> 70; 3. No mental illness.
Exclusion criteria
Exclusion criteria: 1. Contraindications to magnetic resonance scanning; 2. Mental retardation and neurological diseases, major physical diseases; 3. History of traumatic brain injury, MRI examination showed abnormal brain structure; 4. A history of alcohol or drug abuse and dependence; 5. Accept MECT and long-term use of anticholinergic, benzodiazepines and other drugs that may affect cognitive function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Magnetic resonance image of head; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intelligence Quotient;neural cognitive function;social cognitive function;clinical symptoms;social function; | — |
Countries
China
Contacts
Public ContactLu Zheng
Tongji Hospital of Tongji University
Outcome results
None listed