Central Nervous System Diseases
Conditions
Interventions
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Citizens of the People's Republic of China, aged between 18 and 60 years; 2. Causes of CNS injury; 3. The central nervous system injury is mainly manifested as spastic gait: when unilateral is involved, the lower limbs of the affected side straighten outwards and move forward in a circle, walking inwards, sagging toes, and often accompanied by Ipsilateral upper limb flexion and internal rotation. When both sides are involved, it is mainly stiff adduction of both lower limbs. When walking, the front and back crosses are scissors-like, and the toes are mopped. Physical examination of the nervous system is consistent with upper motor neuron injury, including increased muscle tone, hypertenoid reflexes, positive pathological signs, myoclonus, insignificant muscle atrophy, and no muscle fiber tremor; 4. The above items 2 and 3 are independently diagnosed by 2 dyskinesia specialists from the Department of Neurology, Ruijin Hospital; for patients whose diagnosis is in dispute, the professional team of Department of Neurology, Ruijin Hospital will make a collective decision; 5. Fully understand and sign informed consent for this study.
Exclusion criteria
Exclusion criteria: 1. Obvious mental symptoms or severe depression; 2. Patients with significant cognitive impairment (MMSE <20 points); 3. Severe loss of posture reflexes (inability to stand and walk independently), relying on a walker or wheelchair; 4. Rely on nasal feeding tubes for food; 5. Women of childbearing age who were pregnant at the time of enrollment; 6. Have a clear history of brain disease (clear history of stroke, history of traumatic brain injury, history of brain tumors, hydrocephalus); 7. Patients with severe heart, liver, kidney and other medical diseases; 8. Preoperative evaluation found to be unsuitable for spinal cord stimulation; 9. Other situations in which the researcher considers it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Three-dimentional gait analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| MRC muscle strength assessment;Modified Ashworth asticity scale;Clonus grading;Hoffer classification;Holden walking function scale;Tinetti scale;Rivermead moter assessment; | — |
Countries
China
Contacts
Public ContactLi Cao
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed