Lower respiratory tract infection
Conditions
Interventions
Patients with lower respiratory tract infection:Oral single dose of levofloxacin tablet 500mg
Patients with lung surgery:Oral single dose of levofloxacin tablet 500mg
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with lower respiratory tract infection who need diagnostic fiberoptic bronchoscopy for patients over 18 years of age or patients who need lung surgery due to diseases such as lung tumors; 2. Agree to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe pneumonia; 2. Patients with moderate to severe renal dysfunction; 3. Abnormal liver function test: ALT, AST is 3 times higher than the upper limit of normal value or total bilirubin is 2 times higher than the upper limit of normal value; 4. Patients with a history of allergies to fluoroquinolones; 5. Patients with a history of allergies to multiple drugs and a history of light allergies; 6. Patients with a history of epilepsy or other central nervous system disorders; 7. Those with previous QT interval extension or severe cardiac insufficiency; 8. Pregnancy (positive pregnancy test), lactating patients; 9. Subjects had received levofloxacin or other fluoroquinolones within two weeks before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levofloxacin concentration in sputum;Levofloxacin concentration in bronchoalveolar lavage fluid;Levofloxacin concentration in blood;Levofloxacin concentration in the bronchial mucosa;Levofloxacin concentration in the Lung tissue; | — |
Countries
China
Contacts
Public ContactYinyuan Zhang
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed