Mechanism research of gut microbes mediating postoperative nausea and vomiting by microbe-brain-intestinal axis regulating 5-HT/5-HT3 receptors

Gut microbes Mediate Postoperative Nausea and Vomiting by Microbe-brain-intestinal Axis Regulating 5-HT/5-HT3 Receptors

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000029084

Enrollment

Unknown

Registered

2020-01-13

Start date

2020-01-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative nausea and vomiting

Interventions

PONV group:non

non PONV group:non

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients for selective selective total thyroidectomy for thyroid carcinoma under general anesthesia 2. Female aged 18–65 year; BMI 15-28 kg/m2; ASA class I-II; 3. First operation.

Exclusion criteria

Exclusion criteria: 1. Patients with OSAHS 2. Use of analgesic long-term 3. Combidity: Electrolyte disorders; Acidosis; Endocrine disease; Sleep mental cognitive impairment; Severe heart; liver and kidney disease; 4. Use of anxiolyticssedative-hypnoticsantiemetic recently; 5. History of motion sickness; 6. Admission to ICU after surgery; 7. Smoker; 8. History of PONV; 9. Severe vomiting during pregnancy; 10. Gastrointestinal disease including delayed gastric emptying; 11. Vestibular labyrinth system dysfunction; 12. preoperative chemoradiotherapy; 13. used antibiotics two months before surgery.

Design outcomes

Primary

Measure	Time frame
Index of PONV;	—

Secondary

Measure	Time frame
blood 5-HT;	—

Countries

China

Contacts

Public ContactWu Xiaodan

Fujian Provincial Hospital

237190278@qq.com+86 13055291720

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026