depression
Conditions
Interventions
Group 1:real TUS
Group 2:sham TUS
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Meet the DSM-V diagnostic criteria for major depressive disorder (through MINI type examination and clinical diagnosis by a chief physician); agree to receive TUS treatment; 18-50 years old; education level of junior high school and above; Ineffective against 4 weeks of full-dose treatment with an SSRI antidepressant or intolerance to at least one antidepressant; HAMD-17 scale score >=8; the drug type and dosage and conventional treatment during treatment do not change
Exclusion criteria
Exclusion criteria: Reliance on DSM-V drugs or alcohol in the last three months; serious physical illness; having severe negative perceptions and behaviors; pregnant and lactating women; Axis I or Axis II psychotic disorder via MINI diagnoses; ECT treatment is not effective; Any neurological disease, including cerebrovascular disease, stroke, intracranial injury, epilepsy parkinson, etc .; Cardiovascular disease, pacemaker or drug pump installers; Metal implants in the skull; Use of anticonvulsants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD scores;HAMA scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| hemoglobin concentration; | — |
Countries
China
Contacts
Public ContactJijun Wang
Shanghai Mental Health Center
Outcome results
None listed