Circadian rhythm
Conditions
Interventions
The control group:Physiological salt pumping
Experimental group:Dexmedetomidine hydrochloride pumping
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) The American college of anesthesiologists (ASA) grades are grades I to III; (2) Elective surgery; (3) Patients undergoing lower extremity orthopedic surgery under intravertebral anesthesia; (4) Aged 18-65 years.
Exclusion criteria
Exclusion criteria: (1) Patients with operation time less than 30 min; (2) Women who are pregnant or breastfeeding; (3) Abnormal liver function, ALT and/or AST > 1.5 times the upper limit of normal value; (4) Abnormal renal function, Cr and/or BUN > 1.5 times the upper limit of normal value;Dialysis patients; (5) Diabetic patients whose blood glucose was not controlled satisfactorily (fasting blood glucose >= 11.1mmol/L in screening period); (6) The physical condition of the patient is difficult to evaluate the efficacy (such as severe central nervous system surgery or intracranial surgery); Patients with psychiatric disorders (such as schizophrenia, depression) and cognitive dysfunction; Patients with a history of epilepsy; History of cerebrovascular disease; Previous history of abuse of psychotropic drugs and narcotic drugs; Alcohol is invisible; (7) Take benzodiazepines, hormones, beta-blockers, clonidine, ibuprofen and naloxone for the previous 7 days; (8) Patients who need intravenous compound propofol and opioid for poor intraoperative anesthetic effect; (9) Patients who are allergic to the tested drugs; (10) Participate in clinical trials of other drugs within 3 months; (11) The patient does not agree to use the epidural analgesia pump, or the epidural analgesia pump falls off halfway; (12) Other circumstances in which the investigator determines that the patient is not fit to participate in the clinical trial.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Nighttime sleep duration;Daytime sleeping time;Night sleep stage: deep sleep time, light sleep time, rapid eye movement time, sleep cycle awake time;Daytime sleep stage: deep sleep time, light sleep time, rapid eye movement time, sleep cycle awake time;VAS score; | — |
Primary
| Measure | Time frame |
|---|---|
| Deep sleep quality score;Urinary dopamine concentration;Urine concentration of 5 - HT;Urine endorphin levels;Urinary melatonin concentration; | — |
Countries
China
Contacts
Public ContactQingping Wu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed