Intracranial infection
Conditions
Interventions
experimental group:patients received an intrathecal injection of 16mg of NVCM per day and intravenously infused with 800 mg of NVCM, every 12-h
control group:intravenously infused with 800 mg of NVCM, every 12-h
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. This study included neurosurgical patients with lumbar cistern drainage tubes following the operation who were diagnosed in the Neurosurgery Department of the Second Hospital of Hebei Medical University at the ages between 18 and 70. These patients received a norvancomycin treatment for intracranial infections. 2. The diagnostic criteria for the infections were described as follows: 1) a positive MRSA in the CSF cultures; 2) temperature 38 degree C, headache, vomit, and meningeal irritation signs such as nuchal rigidity, Kernigs sign, and Brudzinskis sign; 3) the following abnormalities in the CSF test: WBC count > 1000 x 10^6 cells/L, CSF glucose 500 mg/L.
Exclusion criteria
Exclusion criteria: The following patients were excluded from this study: 1. those who had undergone an antibiotic therapy against gram-positive bacteria, including MRSA during one week prior to the onset of study; 2. those with histories of dysfunctions in lung, heart, liver (alanine aminotransferase or aspartate aminotransferase > 40 U/L), kidney (endogenous creatinine clearance < 10 mL/min), or other organs; 3. those who were female patients at the perinatal period; 4. those with a record of NVCM or vancomycin allergy; 5. those who failed to sustain spontaneous breathing or were in an agonal condition, or in a deep coma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drug concentration in cerebrospinal fluid;cure time;Pharmacokinetic data; | — |
Secondary
| Measure | Time frame |
|---|---|
| CSF WBC;CSF glucose;CSF protein;CSF chloride;adverse reaction;White blood cell count in blood; | — |
Countries
China
Contacts
Public ContactYaqian Li
The Second Hospital of Hebei Medical University
Outcome results
None listed