Hypertension and glucose metabolism disorders
Conditions
Interventions
Spironolactone group:Add-on spironolactone to the original antihypertensive regimen
Non-spironolactone group:Free add-on but not mineralcorticoid receptors antagonists
Sponsors
Hypertension Institution of the People's Hospital of Xinjiang Uygur Autonomous Region; Hypertension Institute of Xinjiang Uygur Autonomous Region
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Male or female patients aged 45–75 years; 2. Office seated systolic blood pressure (SBP)>= 140mmHg or diastolic blood pressure (DBP)>= 90mmHg; or currently under anti-hypertension treatment; 3. Fasting blood-glucose >= 6.1mmol/L or postprandial glucose >= 7.8 mmol/L or diagnosed diabetes; 4. Serum potassium < 4.0 mmol/L.
Exclusion criteria
Exclusion criteria: 1. History of cardiovascular events within last 3 months (including myocardial infarction, heart failure, stroke, unstable angina, coronary revascularization and coronary bypass operation); 2. Renal dysfunction (Scr >= 178 umol/L or eGFR 5ULNALP > 5ULNBIL > 3ULN); 4. Serum uric acid > 520 umol/L); 5. Diagnosed secondary or resistant hypertension (including Cushing syndrome, adrenal tumor, pheochromocytoma, renal hypertension, polycystic ovary symdrome, and congenital adrenal disease) 6. Diagnosed malignant tumor within last 5 years; 7. Pregnant or breastfeeding women; 8. Contraindicated or allergic to spironolactone; 9. Severe mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cardiovascular events;Blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose;kidney function; | — |
Countries
China
Contacts
Public ContactNanfang Li
Hypertension Institution of the People's Hospital of Xinjiang Uygur Autonomous Region; Hypertension Institute of Xinjiang Uygur Autonomous Region
Outcome results
None listed