Severe Infection
Conditions
Interventions
Severe Infection Group:Nanopore sequencing
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Retrospective case study on the period from November 1 to December 31, 2019, the immunodeficiency patients with severe infection hospitalized in hematology department over 14 years old, mainly preimplantation hematopoietic stem cell transplantation patients with the most serious immunodeficiency, do not limit the types of primary diseases (such as leukemia, aplastic anemia, myelodysplastic syndrome), and meet the following conditions: (1) Fever > 38.5 degree C for more than two days; (2) Procalcitonin > 2.5ng/ml or C-reactive protein > 40mg/L, that is, the upper limit of 5 times; (3) collecting a biological body fluid sample to carry out pathogenic microorganism nanopore sequencing detection; (4) Consent to be included in the retrospective case study.
Exclusion criteria
Exclusion criteria: (1) The expected survival period is less than 1 month due to the progression of the primary disease; (2) Patients with transient fever due to drug reaction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival;PROCALCITONIN;C-reactive protein;Body temperature; | — |
Countries
China
Contacts
Public ContactYu Hu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed