Osteoarthritis of the knee
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. patients requiring unilateral initial TKA surgery due to severe knee osteoarthritis; 2. aged 40 to 80 years; 3. body mass index 20~35 kg/m2; 4. the American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) is I ~ III level.
Exclusion criteria
Exclusion criteria: 1. allergic to anesthetic drugs and sulfa; 2. there were more than moderate intraoperative knee malformations (pronation and flexion malformations) and joint stiffness; 3. alcoholic or long-term opioid users; 4. language impairment and inability to perform pain numerical scales (NRS); 5. surgical limb neuropathy; 6. mental patients; 7. patients with previous gastrointestinal ulcer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative dosage of remedial morphine hydrochloride;Time of first postoperative analgesia;VAS pain score;QoR -15 scale;Range of knee motion;Quadriceps strength;Daily walking distance;Time to first straight leg raise;The duration of hospital stay;Incidence of postoperative complications; | — |
Countries
China
Contacts
West China Hospital, Sichuan University