Alzheimer's Disease
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. All patients were diagnosed with dementia caused by AD in 2011, the latest diagnostic criteria for Alzheimer's disease (NIA-AA), according to the patient's clinical and cranial imaging findings; 2. Improved Hachinski ischemic scale score <4; 3. All patients underwent head CT and / or MRI examinations and laboratory tests to rule out other causes of dementia; 4. MMSE (High school<=24, Primary school<=20; illiteracy<=17); 5. The subjects and nurses signed informed consent, and the nursing staff were able to take responsibility for the supervision of the participants; 6. The subjects were stable; 7. Cooperate, willing to complete all parts of the research, and have the ability to complete the study alone or with the help of the nursing staff.
Exclusion criteria
Exclusion criteria: 1. Patients =2mm(if there were imaging evidence of cerebral infarction in subcortical, periventricular and deep brain, but no symptoms and corresponding history were excluded), Hachinski ischemic score was >4; 4. Existingcentral nervous system infection, cephalic injury, epilepsy, multiple sclerosis, toxic metabolic disease; 5. Parkinson's disease, intracranial tumor, hypothyroidism; 6. Schizophrenia, a history of personality changes in mental illness; Severe heart, liver, kidney, brain and hematopoietic diseases; 7. Contraindications for MRI scans such as electronic and metal device implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination;Mattis Dementia Rating Scale;Assessment of Daily life Ability;Clock Drawing Test;Hamilton Depression Scale;memory capacity applying the Auditory Verbal Learning Test;Rey-Complex Figure Test;Logical Memory Test;figure naming test and verbal fluency test;Digital Span Test;Digital-Symbol Switch Test;Trail Making Test;Stroop Color-word test;semantic similarity test;Hachinski Ischemic Score;ADAS cog;QOL AD;NPI;GDS;ERP-P300;fMRI; | — |
Countries
China
Contacts
Public ContactWu Ting
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed