Colonization and infection of CRKP
Conditions
Interventions
Healthy control group:Nil
critically ill patients with CRKP negative:Nil
critically ill patients with CRKP positive:Nil
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for healthy subjects: 1. Healthy; 2.18 Years and older; 3. Agree of giving written informed consent by subjects; 4. Physical examination without any clinically relevant abnormality; 5. Normal defecation pattern. Inclusion criteria for critically ill patients: 1. 18 Years and older; 2.Addmited to medical ICU; 3. Agree of giving written informed consent by patients or legal custodian; 4. Patients who have an expected length of ICU stay of > 24 hours.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for healthy subjects: 1. History of any chronic medical illness, like hypertension and diabetes and so on; 2. History of any type of malignancy; 3. History of any digestive system disease; 4. History of any communicable disease; 5. Subject uses tobacco products; 6. History of alcoholism;7. History of any drug abuse; 8. Use of antibiotics within 12 months; 9.Pregancy or breast feeding. Exclusion Criteria for critically ill patients: 1. Routine screening for CRKP by rectal swabs is positive within 48h after ICU admission; 2. Life expectancy < 24 hours; 3. History of any ICU hospitalization; 4. Pregancy or breast feeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota;Rate of CRKP colonization;Rate of CRKP infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Screening positive time for CRKP ;ICU length of stay;Hospital length of stay;ICU mortality;Hospital mortality;28-day-mortality; | — |
Countries
China
Contacts
Public ContactZhiyong Zong
West China Hospital of Sichuan University
Outcome results
None listed