Contast-induced Acute Kidney Injury
Conditions
Interventions
Experimental group 1:Low dose of tolvaptan (3.75mg) and standard intravenous hydration
Experimental group 2:High dose of tolvaptan (7.5mg) and standard intravenous hydration
Control group:Standard intravenous hydration
Sponsors
Zhongda Hospital of Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Volunteered to participate in this trial and signed informed consent; (2) Aged 18 to 85 Years; (3) Planned coronary interventional procedures; (4) AGEF scores>1.16; (5) No associated contraindications.
Exclusion criteria
Exclusion criteria: 1. Hypersensitivity to iodine-containing compounds and patients who meet the contraindications in the instructions of tolvaptan: patients who are allergic to the clinical application of tolvaptan; patients in urgent need of rapidly increasing serum sodium concentration; patients with hypernatremia;patients who are insensitive to thirst or unable to respond normally to thirst; patients with hypovolemic hyponatremia; patients with anuria; Combined with potent CYP3A inhibitors; 2. Lactation, pregnancy; 3. Present or suspected acute kidney injury; 4. Use tolvaptan, contrast agent and renal toxicity drug within 1 week; 5. Severe renal insufficiency requiring hemodialysis; 6. Use IABP, acute heart failure, liver failure, connective tissue disease, tumor, severe infectious disease, cardiogenic shock in hospital, sudden cardiac death, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of contrast-induced acute kidney injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) the actual or percent (%)change of serum creatinine, eGFR, sodium, and brain natriuretic peptide within 72 h after the administration of contrast medium,and abdominal CT was performed 24 hours after surgery to evaluate the residual contrast agent;(2) major postprocedural in-hospital adverse events, including cardiogeni; | — |
Countries
China
Contacts
Public ContactGaoliang Yan
Zhongda Hospital of Southeast University
Outcome results
None listed