Idopathic sudden sensorineural hearing loss
Conditions
Interventions
experimental group:Apply methylprednisolone 48mg/d throughout the day for 7 days, then gradually reduce the amount for 3 days for a total of 10 days. At the same time, 40 mg / mL methylprednisolone wa
control group:The whole body was treated with methylprednisolone 48mg/d for 7 days, then gradually reduced for 3 days for a total of 10 days.
Sponsors
The First Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Signing informed consent; 2. Age greater than 18 and less than 75 years old; 3. Diagnosis of unilateral sudden sensorineural hearing loss; 4. Sensorineural hearing loss occurred within 3 days, at least in the adjacent two frequencies, the hearing loss exceeds 20dB, usually the cause is unknown, accompanied by tinnitus, ear nausea, dizziness and other symptoms; 5. The recovery of the ISSNHL is insufficient for at least 12 days, regardless of whether the patient receives any treatment (ie, the hearing of the contralateral ear is at least 20 dB higher than the affected ear at at least three frequencies (any three of 500, 1000)).
Exclusion criteria
Exclusion criteria: 1. Positive pregnancy test, risk of pregnancy (insufficient protection or insufficient lactation); 2. Otitis media or effusion, external auditory canal; 3. Conductive hearing loss greater than 10dB; 4. There are any conditions or symptoms that indicate that hearing loss is not ISSNHL, such as acoustic trauma, Meniere's disease, hearing fluctuations, endolymphatic edema, suspected recurrent cochlear lesions, hearing loss due to ear surgery, perilymphatic fistula or barotrauma; 5. The history of ototoxic treatment in the past 6 months, such as chemotherapy, the use of loop diuretics, high doses of aspirin. 6. A history of allergy, allergy or intolerance or any serious abnormal drug reaction to the study drug is known. 7. Any systemic nervous system disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pure tone average; | — |
Secondary
| Measure | Time frame |
|---|---|
| Speech recognition rate; | — |
Countries
China
Contacts
Public ContactXianren Wang
Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed