Asthmatic disease
Conditions
Interventions
Control group:Conventional treatment
Experimental group:Conventional treatment + nebulized IFN-a1b
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
0.5 Years to 5 Years
Inclusion criteria
Inclusion criteria: 1. aged 0.5-5 years old; 2. acute infection, clinical symptoms: fever, wheezing, cough, lung rales, wheezing, etc 3. lower respiratory tract infection caused by viru(clinical diagnosis was associated with respiratory viral infection, nasopharyngeal secretions of etiology detection of respiratory syncytial virus (RSV), adenovirus (ADV), influenza virus type A (IVA), type B (IVB), parainfluenza I type (PIV I), II (PIV II) and III (PIV III), at least one was positive); 4. Onset time<=96 hours; 5. IVIG and other biological and chemical immunoregulatory agents and antiviral agents were not used in the first week of treatment; 6. Willing and able to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergic history of interferonor contraindication to interferon; 2. severe wheezing with respiratory failure and serious complications; 3. With bronchopulmonary dysplasia, congenital airway dysplasia, bronchiectasis, bronchial foreign body, lobar pneumonia and tuberculosis; 4. WBC 12*10^9/L,classification of neutrophils significantly increased; 5. history of epilepsy or other central nervous system diseases; 6. other serious diseases, such as severe malnutrition, serious liver and kidney function damage, active peptic ulcer disease, fracture, adrenal hyperfunction, diabetes, cardio-cerebrovascular, tuberculosis, chronic obstructive pneumonia, mental disease, etc.; 7. Unable to cooperate with the study; 8. Those subjects are not suitable for this study by investigator's judgement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alleviate clinical symptoms;Clinical curative effect; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospitalization time;Biochemical index detection;frequency and incidence of recurrence; | — |
Countries
China
Contacts
Public ContactZhou Fu
Outcome results
None listed