Risk prediction model based on gut microbiome composition predicts perioperative infection risk in children with congenital heart disease

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000028738

Enrollment

Unknown

Registered

2020-01-02

Start date

2019-12-01

Completion date

Unknown

Last updated

2021-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital heart disease

Interventions

Infection group:None

No infection group:None

Eligibility

Sex/Gender

All

Age

No minimum to 6 Years

Inclusion criteria

Inclusion criteria: 1. Children with congenital heart disease who underwent cardiac surgery under cardiopulmonary bypass; 2. Aged 0-6 years.

Exclusion criteria

Exclusion criteria: 1. Suffered from gastrointestinal diseases in the last two months; 2. Take hormone and other immunosuppressants in the last two months; 3. Had a surgical operation in the last two months; 4. Infectious disease in the last two months; 5. Broad-spectrum antibiotics were used in the last two months; 6. Chromosome malformation; 7. Respiratory diseases; 8. Immunodeficiency disease; 9. Stunted growth or severe malnutrition.

Design outcomes

Primary

Measure	Time frame
Blood culture infection record;Fecal culture infection record;Sputum culture infection record;Throat swabs culture infection record;	—

Secondary

Measure	Time frame
interleukin-22;interleukin-10;interleukin-6;TNF-a;C-reactive protein;IgA;IgE;IgM;plasma fatty acid-binding protein;plasma LPS;	—

Countries

China

Contacts

Public ContactShou-jun Li

Fuwai Hospital, Chinese Academy of Medical Sciences

drlishoujun@yahoo.com+86 010 88398855

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026