Prostate cancer
Conditions
Interventions
Case series:Focused ultrasound ablation
Sponsors
National Engineering Research Center for Ultrasound Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed low-risk / medium-risk prostate cancer: (1) Gleason score 6 - 7 points (3 + 3, 3 + 4 or 4 + 3); (2) PSA=3 points; 3. Life expectancy is >=10 years. 4. There are indications for radical prostatectomy (RP) for patients with prostate cancer and they are willing and have chosen to receive RP; 5. Safe acoustic path and focus can reach the target area; 6. Target area can be detected by real-time ultrasound.
Exclusion criteria
Exclusion criteria: 1. Prior treatments: endocrine therapy (androgen deprivation therapy (ADT), a reductase inhibitors and / or other hormonal therapy), prostate surgery (transurethral resection of the prostate within 6 months/), radiotherapy / local radioactive particle implantation, other local prostate treatments (including radiofrequency ablation and cryotherapy); 2. Rectal diseases; 3. There are calcifications in the prostate that can affect the energy deposition or safety of ultrasound; 4. Bladder or lower urinary tract stones; 5. Active urinary tract infection; 6. Metal implants / stent in the urethra; 7. Patients cannot keep lithotomy position; 8. Patients with strong requirements of keeping sexual function / fertility; 9. Patients with other malignancies; 10. Contraindications to MRI scans; 11. Cannot understand or refuse to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coagulative necrosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| prostate specific antigen, PSA;Changes in target blood flow perfusion; | — |
Countries
China
Contacts
Public ContactYong Liang
Zigong Fourth People's Hospital
Outcome results
None listed