bipolar disorder
Conditions
Interventions
Group A:Sulforaphane (ZHIYINGUOSU, Shenzhen Fushan Biotech Co., Ltd.)
Group B:placebo
Sponsors
The First Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) males or females aged 16 to 65 years old; (2) agree to participate in the research and sign the informed consent form; (3) the subjects biological parents are Han; (4) diagnosed with bipolar depressive disorder according to the DSM-IV (the fourth Edition of Diagnostic and Statistical Manual of Mental Disorders) diagnostic criteria; (5) score more than or equal to 17 points on the Hamilton Depression Scale (HAMD) at screening and baseline period; (6) score less than or equal to 5 points on the Young Mania Rating Scale (YMRS) at screening and baseline period; (7) no taking any drug treatment or no receiving antidepressant treatment in the last 1 month; (8) take drugs by oneself during the study period, or have a regular helper to help with the medication.
Exclusion criteria
Exclusion criteria: (1) diagnosed with other spectrum disorders according to the DSM-IV diagnostic criteria; (2) mental disorder caused by substance abuse, or serious physical diseases; (3) received antibiotics within 1 month before enrollment due to respiratory tract, urinary tract, the digestive system infection; (4) subjects with a history of attempted suicide, or currently at high suicide risk, or with suicide behavior/attempt, or scoring more than or equal to 3 points on the 10th clause of Montgomery Asberg Depression Rating Scale (MADRS); (5) unwilling to take the medicine; (6) known pregnancy, lactation, or pregnant planning; (7) the subjects with contraindications of quetiapine or have used quetiapine but have poor efficacy; (8) allergic to broccoli; (9) Received electroconvulsive therapy within one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 17 items of Hamilton depression scale;Montgomery depression scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton anxiety scale;Depression symptom self-rating scale;Young Mania Rating Scale;inflammatory factor;neurocognitive function assessment; | — |
Countries
China
Contacts
Public ContactShaohua Hu
The First Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed