Knee osteoarthritis
Conditions
Interventions
Group 1:Platelet rich plasma group
Group 2:Autologous peripheral blood mononuclear cell group
Sponsors
Xiangyang 1st People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) in line with the 2018 edition of "guidelines for the diagnosis and treatment of osteoarthritis" issued by joint surgery group, Chinese association of osteology (2) the knee osteoarthritis K - L classification stage II, III; (3) aged than 40-75 years; (4) VAS score of pain scale is greater than 3 points; (5) did not take any treatment for knee osteoarthritis within 3 months; (6) good compliance, willing to cooperate with the study, and the patient signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) osteoarthritis of the knee other than degenerative osteoarthritis; (2) the knee joint is severely deformed and cannot be evaluated and treated; (3) systemic or local inflammatory symptoms within 2 weeks before surgery; (4) female patients had menstrual period 3 days before surgery; (5) the skin condition at the puncture site is not good, and the puncture cannot be carried out normally; (6) affecting the quality of cells in patients with disease, such as poorly controlled diabetes (> 10.0 tendency for fasting glucose/L), poor control of high blood pressure, blood pressure > 160/100 MMHG), coagulation dysfunction, bone marrow transplant, active hepatitis, decompensated liver cirrhosis, the need for auxiliary breath, endogenous creatinine clearance < 50 m/min, cardiac function NYHA stage acuity ? etc. (7) have any known disease that seriously affects the immune system, such as a history of infection with the human immunodeficiency virus (HIV), or malignant tumors of the blood system or solid organs in the progressive stage, or splenectomy; (8) pregnant or nursing women; (9) inability to communicate normally and incapacitated, history of epileptic seizures, or psychiatric disorders that may affect compliance with the program, or risk of suicide, or history of alcohol or illicit drug abuse; (10) have participated in or are participating in other clinical trials within 3 months prior to enrollment; (11) other circumstances in which the researcher considers it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC; | — |
Secondary
| Measure | Time frame |
|---|---|
| X-ray;MRI;ECT;IKDC;EQ-5D;SF-12;K-L;Motion picture;Physical check;arthroscopy; | — |
Countries
China
Contacts
Public ContactPei Bin
Xiangyang 1st People's Hospital
Outcome results
None listed