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Key gene of retinal cholesterol metabolism network in lutein against age-related macular degeneration

A study of the key gene of retinal cholesterol metabolism network in lutein against age-related macular degeneration

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900028680
Enrollment
Unknown
Registered
2019-12-30
Start date
2019-12-31
Completion date
Unknown
Last updated
2020-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age-related macular degeneration

Interventions

Placebo:Placebo
Lutein group:Lutein 10mg/d
Lutein and DHA group:Lutein 10mg and DHA 60mg

Sponsors

Xi'an Jiaotong University Health Science Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 45 and 90 years; 2. Diagnosed as early age-related macular degeneration.

Exclusion criteria

Exclusion criteria: 1. Patients with exudative age-related macular degeneraton; 2. Suffering from other retinal or choroid lesions diseases; 3. Suffering from severe cardiovascular disease, respiratory disease, neurological disease or servious renal impairment; 4. Suffering from diseases that affect nutrient absorption or digestive tract diseases, such as crohn's disease; 5. Taken lutein and it's related nutritional supplements in the past half a year.

Design outcomes

Primary

MeasureTime frame
Changes of serum carotenoids concentrations during the intervention;—

Secondary

MeasureTime frame
Changes of macular pigment optical density during the intervention;Changes of contrast sensitivity during the intervention;Dietary total carotenoid capacity of participants;Key genes in participants' cholesterol metabolism network;—

Countries

China

Contacts

Public ContactMa Le

Xi'an Jiaotong University Health Science Center

male@mail.xjtu.edu.cn+86 18202906588

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026