tuberculosis
Conditions
Interventions
Pulmonary Tuberculosis:no
Tuberculous meningitis:no
Disease control (non-PTB):no
Disease control (non-MTB):no
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
16 Years to 80 Years
Inclusion criteria
Inclusion criteria: Cases: 1. Patients with clinically diagnosed tuberculosis (including tuberculosis, bronchial tuberculosis and tuberculous pleurisy, which can be accompanied by extrapulmonary tuberculosis, and the diagnostic criteria are ws288-2017), and the primary treatment; 3. Before receiving anti-tuberculosis treatment, the duration of antibacterial drugs was less than 1 week; Non-cases control group: 1. Acid-fast smear and tuberculosis culture were negative, and tuberculosis infection was excluded after clinical diagnosis; 2. Clinically diagnosed as pulmonary infectious disease or early neoplastic disease; Healthy control group: 1. No history of tuberculosis; negative MTB test including acid-fast staining smear, culture and TB-DNA test; 2. Proved to be a healthy person by physical examination.
Exclusion criteria
Exclusion criteria: 1. HIV, hepatitis B, syphilis, hepatitis C and other infectious diseases; 2. A long history of medication, such as immunosuppressants; 3. Chronic and metabolic diseases, such as diabetes, hypertension, allergic diseases, asthma, obesity, or other end-stage diseases; 4. The researchers determined that the patients were not suitable for inclusion in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| outcome of treamtent;adverse drug reactions;RNA expression;Microbial flora ratio;Intestinal metabolite content; | — |
Secondary
| Measure | Time frame |
|---|---|
| smear conversion rate;culture conversion rate;Lesions change; | — |
Countries
China
Contacts
Public ContactBinwu Ying
Outcome results
None listed