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Combined use of hydration and reduced glutathione for preventing contrast-induced nephropathy following percutaneous coronary intervention in elderly patients with diabetes

Combined use of hydration and reduced glutathione for preventing contrast-induced nephropathy following percutaneous coronary intervention in elderly patients with diabetes

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900028664
Enrollment
Unknown
Registered
2019-12-29
Start date
2016-08-01
Completion date
Unknown
Last updated
2020-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contrast-induced Nephropathy

Interventions

Experimental group:Combined use of hydration and reduced glutathione
control group:hydration

Sponsors

Taizhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 83 Years

Inclusion criteria

Inclusion criteria: All elderly patients with coronary heart disease were older than or equal to 65 years old, with type 2 diabetes mellitus, and received PCI.

Exclusion criteria

Exclusion criteria: 1. refusal to participate in the clinical trial; 2. refusal to PCI treatment; 3. perioperative use of any nephrotoxic drugs; 4. severe hepatic and renal failure; 5. severe infectious diseases; 6. New York Heart Association Functional Classification (NYHA) class >3; 7. hemodynamic instability, including systolic blood pressure below 90 mmHg; 8. coronary artery lesions did not meet the revascularization treatment standard; 9. coronary artery anatomy not suitable for PCI; 10. allergic reaction to contrast media and reduced glutathione.

Design outcomes

Primary

MeasureTime frame
Serum creatinine;Creatinine clearance;—

Contacts

Public ContactJiangguang, Yang

Taizhou First People's Hospital

yangan2228@hotmail.com+86 15858628088

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026