Clinical application of vaginal microecological detection and bacterial spectrum analysis during pregnancy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900028662

Enrollment

Unknown

Registered

2019-12-29

Start date

2019-12-30

Completion date

Unknown

Last updated

2020-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vaginal microecology and bacterial spectrum during pregnancy

Interventions

Healthy non-pregnant women:Nil

Bacterial vaginitis in non-pregnant women:Nil

Vulvovaginal candidiasis in non-pregnant women:Nil

Trichomonas vaginitis in non-pregnancy:Nil

Symptoms of vaginal inflammation but no pathogenic bacteria detected in non-pregnancy:Nil

Healthy pregnant women (early pregnancy, middle pregnancy, late pregnancy):Nil

Bacterial vaginitis in pregnant women (early pregnancy, middle pregnancy, late pregnancy):Nil

Vulvovaginal candidiasis in pregnancy (early pregnancy, middle pregnancy, late pregnancy):Nil

Trichomonas vaginitis in pregnancy (early pregnancy, middle pregnancy, late pregnancy):Nil

Vaginal inflammation symptoms during pregnancy but no pathogenic bacteria were detected (early pregnancy, middle pregnancy, late pregnancy):Nil

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Female married or sexual history, menstrual regularity, age 18 to 40 years, clean menstruation for more than 3 days, no sexual life within 3 days, no history of systemic or vaginal medication within 2 weeks, exclusion of other gynecological disorders. BV: using Amsel clinical diagnostic criteria: 1. positive clue cells; 2. homogeneous, thin, off-white vaginal discharge; 3. pH> 4.5; 4. positive amine test, with 3 of them. TV group: Trichomonas found in vaginal secretions; VVC group: sporozoites or pseudohyphae of candida found in vaginal secretions; Healthy group: no symptoms of vaginal inflammation and no pathogenic bacteria detected by conventional methods of vaginal discharge.

Exclusion criteria

Exclusion criteria: 1. Combined with a history of other diseases; 2. Have a long history of taking medication; 3. Cannot follow up.

Design outcomes

Primary

Measure	Time frame
vaginal microecological detection;Bacterial PCR gene detection;16s rRNA gene amplification and sequencing;Pregnancy outcome;	—

Countries

China

Contacts

Public ContactHongbo Chen

Hefei Maternal and Child Health Care Hospital

chenhongbo@ahmu.edu.cn+86 18056076983

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026