Perimenopausal Syndrome
Conditions
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women over 40 years old; 2. According to the diagnosis of perimenopausal syndrome, there were more than two changes in the length of the adjacent menstrual cycle > 7 days in 10 months, and FSH > 10u/L (those with menstruation were still detected within the second to third days of menstrual cycle); 3. The score of modified Kupperman index was more than 15; 4. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Uterine fibroids > 3cm, or adenomyosis, or endometriosis, or bilateral ovariectomy, or severe hyperplasia of the breast, or malignant tumors of the reproductive system; 2. The vagina irregular bleeding with unknown cause was not cured; 3. Patients with severe primary diseases or psychosis, such as cardiovascular, cerebrovascular, liver, kidney, endocrine and hematopoietic system; 4. Those who have used sex hormone drugs in the past 3 months; 5. Presence of conditions affecting oral drug absorption (such as gastrectomy); 6. Patients with allergic constitution; 7. Those who have used antibiotics in the past 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The score of modified Kupperman index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum sex hormone level;Gut microbiota structure;Menopause Rating Scale; | — |
Countries
China
Contacts
Public ContactYing Zhou
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed