Central nervous injury during perioperative period
Conditions
Interventions
Experimental group:Dexmedetomidine
Control group:Normal saline
Sponsors
Fuwai Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Years to 3 Years
Inclusion criteria
Inclusion criteria: (1) Age: 1-3 years old; (2) The legal guardian or agent of the child agrees to participate in this study and signs an informed consent form; (3) The main preoperative diagnosis of the child is atrial septum defect or ventricular septum defect.
Exclusion criteria
Exclusion criteria: (1) The child has a family history of mental retardation or related diseases before surgery; (2) The child has a history of brain trauma; (3) The child has contraindications to dexmedetomidine; (4) Preoperative examinations show that the child has inflammation or infection and does not receive effective treatment; (5) The duration of cardiopulmonary bypass is less than 15 min or more than 75 min; (6) The duration of aortic cross-blocking is less than 10 minutes or more than 60 minutes; (7) The child is diagnosed preoperatively or postoperatively as severe pulmonary hypertension; (8) The child is identified to be combined with other cardiac or vascular malformations (except patent ductus arteriosus, patent foramen ovale, mild aortic insufficiency, mild tricuspid insufficiency, mild mitral insufficiency); (9) The child has perioperative complications that may affect the test results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative serum (or plasma) s100 concentration;Perioperative serum (or plasma) NSE concentration level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative serum (or plasma) inflammatory factors (interleukin 1,6 and TNF) levels.;Perioperative serum (or plasma) hormone (norepinephrine) concentration levels;Preschool Scale of Intelligence; | — |
Countries
China
Contacts
Public ContactZhe Zhang
Fuwai Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed